日本動物学会北海道支部 第612回支部講演会

日時：2026年6月9日（火）　17:00～18:30

場所：北海道大学 理学部5号館8階 813号室

演者：⼭尾 啓熙 博士（Institute of Neurobiology, Faculty of Mathematics and Natural Sciences, Heinrich Heine University Düsseldorf）

演題：Astrocyte-mediated regulation of fear memory fate（アストロサイトによる恐怖記憶の運命決定制御）

要旨：Animals exploit regularities in the environment by storing memories and later using them to guide behavior. Astrocytes may modulate neuronal meta-plastic states, thereby influencing memory

formation during highly salient experiences, such as intense fear. Here, we combined classical fear conditioning with in vivo astrocyte optogenetic manipulations, fiber photometry recordings, and ex vivo measurements to investigate the role of amygdala astrocytes in fear memory. Optogenetic perturbations during conditioning selectively altered long-term and remote memory formation, without simply disrupting immediate memory acquisition. These findings suggest that amygdala astrocytes act during a brief window around fear experience to regulate the long-term fate of memory. To assess whether astrocytes show physiologically relevant activity, astrocyte activity patterns were assessed in vivo and ex vivo to identify dynamics that underlie their possible roles in memory modulation.

世話人：

小川 宏人（北海道大学 理学研究院）

hogawa[a]sci.hokudai.ac.jp

[a]を@に変えてください

エゾリス（旭川医科大学RI実験施設　長原稔和氏提供）